A couple of weeks ago, I finally moved in with my husband, which was supposed to be the beginning of a wonderful chapter in our lives. I had no idea that my husband’s 15-year-old son from a previous marriage, named Dave, would prove to be a difficult obstacle to overcome. Though I knew there would be some period of adaptation, I did not expect such an attitude towards my efforts to make the house our cozy place in the form of piles of garbage that Dave, as if on purpose, left scattered throughout the house.
At first, I thought it was a temporary situation, perhaps a teenager’s version of chaos. But days turned into weeks, and the mess only seemed to grow. Empty chip bags, crumpled papers, and discarded clothes adorned every corner of our once-pristine home. It was as if a tornado of teenage negligence had swept through, leaving behind a debris field that would shock even a loving mother.
My comments and requests for cleanliness had no effect on him at all. It was like talking to a wall. I wanted to stop this and somehow decided to act outside the box.
One day, when Dave left for school, I came up with a plan. I was going to defeat this trash invasion, which required a strategy that went beyond mere words. Wandering around the house, armed with trash bags and determination, I picked up every piece of clutter that had settled into our home. I was on a mission to teach Dave a lesson in responsibility.
His room, the center of chaos, was my first target. When I walked in, I was greeted by clothes strewn across the floor, a maze of crumpled papers, and a collection of half-empty soda cans. Without pleasure, but with a feeling of determination, I began to put all the items that were scattered in garbage bags. Papers, cans, his clothes, everything was packed into the bags together. In the end, the room gradually turned from a disaster zone into something resembling order. I packed all the scattered clothes with other trash in a bags.
A similar fate befell the living room, kitchen, and even the bathroom. It was a time-consuming task, but I was sure that if words could not reach him, perhaps these bags would show him how much of a mess he left behind.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Leave a Reply