The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My Husband Skipped Our Baby’s Gender Reveal Appointment – It Was the Last Straw and He Deserved a Lesson
As many married couples can attest, the journey towards parenthood is one that is often envisaged as being shared equally between both partners. I held a strong conviction that my pregnancy would be a time of shared joy and responsibility with my husband. I imagined us attending each prenatal appointment together, his hand in mine, as we listened to the heartbeat of our unborn child, eagerly discussing our future with excitement and tenderness. Sadly, the reality I faced was starkly different. It became increasingly apparent that my husband was more inclined to prioritize his social life and personal interests, repeatedly sidelining our important prenatal milestones. This recurring pattern of neglect ultimately pushed me to a point where I felt compelled to teach him an unforgettable lesson.
From the moment we discovered I was pregnant, it felt as if we had stepped into a dream. For years, my husband and I had looked forward to starting a family, and now, it seemed our dreams were finally coming to fruition. The news came to us during a short romantic getaway, which felt like the universe’s way of telling us that our lives were about to change for the better. We knew that the journey ahead would be fraught with challenges, but we were ready—or so I thought—to face them together.
In the early weeks, my excitement was palpable. I approached every aspect of pregnancy with a positive spirit, even the less pleasant moments like morning sickness, because I believed that having my husband’s support would make the challenges manageable. However, his lack of involvement soon became evident. It seemed he viewed the pregnancy as my sole responsibility, an ordeal I must face alone while he maintained the freedom of our pre-parenthood days.
During the first trimester, there were nights filled with discomfort and restlessness, where the cold bathroom floor became my refuge. Meanwhile, my husband slept soundly, undisturbed and seemingly oblivious to my struggles. Even a simple gesture of fetching a glass of water seemed too much to ask of him. I found myself growing resentful, feeling abandoned in what was supposed to be our shared journey. I couldn’t help but think, “If I am already doing the job of being pregnant, the least he could do was rub my feet, or help when I am dealing with the worst nausea. I mean the child is not only his when it’s born.”
Our excitement soon soured into tension and frequent arguments. I had hoped that we would at least be able to share the experience of prenatal appointments, but my husband’s attendance was sporadic. He often opted out, preferring to engage in leisure activities with his friends. His excuses were flimsy, and whenever I expressed my disappointment, he dismissed my concerns with a shrug, saying, “I’m not the one carrying the baby, why do I have to go see the doctor with you?”
The turning point came when we were scheduled to attend an appointment to learn the gender of our baby. This was a moment I had envisioned as a milestone for us as a couple, an experience that would further bond us to our child. However, at the last minute, he decided to skip the appointment to enjoy a casual meal of fish ‘n’ chips with a friend. I was devastated and furious, but I managed to keep my composure. Instead of him, my mother accompanied me, and together, we discovered that we were expecting a daughter.
Resolved to make my husband realize the significance of his absence, I planned a poignant reminder for our gender reveal party. I commissioned a cake that was outwardly ordinary, decorated with question marks. However, hidden inside was a unique twist meant to symbolize his recent choices.
At the party, surrounded by friends and family, I asked my husband to do the honors of cutting the cake. As he sliced through the cake, out poured not the traditional blue or pink hues but miniature, edible fish ‘n’ chips. The symbolism was not lost on anyone—this was the meal he had deemed more important than attending the gender reveal of his own child. The room erupted in laughter, and while the atmosphere was light, the message hit home. It was a playful yet serious reminder of what he had missed. Taking advantage of the lighthearted mood, I expressed how crucial it is for us to support each other, especially during such a transformative phase of our lives.
Following the laughter and initial surprise, I presented the real reveal—a second cake, this one intricately decorated in soft pastel colors with delicate baby footprints. Together, we cut into it, revealing a beautiful soft pink interior. The room cheered, “It’s a girl!” The joy and excitement were overwhelming, and it was clear that the message had been received.
The realization of what he had been neglecting seemed to dawn on my husband. His apology that night was heartfelt, and from that day forward, he became a more present and involved partner. He attended every subsequent appointment without fail, and his newfound commitment to our prenatal journey was unmistakable.
As we continued to prepare for the arrival of our daughter, the atmosphere in our home shifted from one of tension to one of eager anticipation. We started planning the nursery, selecting each piece of furniture with care. My husband took particular interest in building some of the furniture himself, showcasing a level of engagement that was both surprising and heartening.
The incident with the fish ‘n’ chips cake became a legendary story within our family, a humorous but poignant reminder of the importance of being present and supportive. It served not only as a lesson for my husband but also as a reminder to both of us about the significance of shared experiences and mutual support in our marriage.
Reflecting on the journey, it became clear that the challenges we faced were not merely obstacles but opportunities for growth. They strengthened our relationship, deepening our understanding and appreciation for one another. As we awaited the arrival of our daughter, we were not just preparing to be parents but also learning to be better partners to each other. This experience, though fraught with initial misunderstandings and adjustments, ultimately enriched our bond and reinforced the foundation upon which our growing family would stand.
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