The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Baby Girl Dies After Being Left in Hot Car Just Two Months After She Was Adopted By a San Diego Couple
A heartbreaking incident has unfolded in Santee, San Diego, where a baby girl lost her life after being left in the back of a hot car. This tragic event occurred just two months after her adoptive parents brought her home. Is hot car death common?
Discovery and Emergency Response Into The Hot Car Death – An Ongoing Investigation
Diana Sofia Aleman Roman, the infant victim, was found unresponsive in the SUV parked outside her family’s home around 12:20 AM on June 13. The child had been left in the vehicle for several hours in 63°F weather before a family member discovered her and immediately called 911.
Despite being rushed to Sharp Grossmont Hospital, Diana could not be saved. The San Diego County Sheriff’s Office is actively investigating the circumstances that led to Diana being forgotten in the car and determining who was responsible. As of now, no charges have been filed.
The Dangers of Hot Cars – a Tragic Hot Car Death
Studies highlight the rapid rise in temperature inside a parked car. On a 70°F day, the temperature inside a car can soar to 104°F within just half an hour. Reaching 115°F in an hour. The human body’s organs begin to shut down at 107°F, making such environments lethal, especially for children.
Adoption and Family Background – A Loving Family
Diana was welcomed into the home of Romer and Jayson De Los Santos on April 11, after they traveled to Arizona to meet her in the hospital. Heartwarming photos captured the couple cradling Diana and introducing her to their two-year-old son, who was also adopted. Romer expressed his grief after the hot car death, writing, “I haven’t slept in days,” next to one of the photos.
The De Los Santos family had been actively seeking to adopt a second child, sharing their adoption profile on social media in November. They expressed their desire to provide a loving home filled with cherished memories. Special moments such as beach outings, biking to the park, and raising foster kittens. Romer, a senior consultant at Jama Software, and Jayson, a stay-at-home dad, have been together for over 20 years. They married in 2008 during a brief period when same-sex marriage was legal in California. Their home is described as a “zoo,” housing numerous pets including cats, dogs, chickens, and parakeets.
Community Reaction
Neighbors described the De Los Santos family as kind and attentive parents often seen playing outside with their children. One neighbor said, “They seem like a nice family who wanted to give a couple of kids a good life. It’s just a shame it didn’t turn out that way.” It seems many suggested that the hot car death wasn’t intentional.
Medical Examination and Broader Context
The San Diego County Medical Examiner’s Office will determine the cause and manner of Diana’s death. Annually, around 37 children die from being left in hot cars across the U.S. Since 1998, California has witnessed at least 56 such fatalities, according to statistics from San Jose State University’s No Heat Stroke project.
Preventive Measures and Legal Implications & Expert Insights
Parents are urged never to leave their children alone in vehicles, even for short periods. Temperatures can rise dangerously fast, posing severe risks to children who cannot regulate their body temperatures as efficiently as adults. Which can effectively cause hot car death. California law imposes a $100 fine for leaving a child under six in a car under hazardous conditions. With potential charges ranging from neglect to manslaughter depending on the outcome.
Experts explain that it’s possible for any parent to forget a child in a car, especially when distracted or following routine habits. The increase in such cases since the 1990s is partly attributed to the recommendation of placing child car seats in the back, out of sight to protect them from airbags.
Recommendations for Prevention
To avoid such tragedies, No Heat Stroke suggests placing a soft toy in the front seat as a reminder of the child in the back or placing essential items next to the child’s seat. They also recommend keeping vehicles locked at all times and teaching children never to play in cars.
The loss of Diana Sofia Aleman Roman serves as a stark reminder of the dangers associated with leaving children unattended in vehicles and the importance of vigilant parenting practices. Hot-car tragedies can happen to anyone due to human memory lapses.
Here are key strategies to prevent these incidents:
Create Safeguards: Establish agreements with child-care providers to notify each other if a child is absent or late. Set phone reminders to ensure the child has been dropped off.
Secure Vehicles: Always keep vehicles locked and keys out of children’s reach.
Visual Reminders: Place the child’s items, such as a diaper bag or jacket, in the front seat as a reminder.
Back-Seat Checks: Keep essential items like your backpack or briefcase in the back seat to prompt a check before leaving the car.
Never Leave Children Unattended: Never leave a child alone in a vehicle, regardless of the outside temperature.
Technological Solutions & Expert Advice:
Invest in car seats or vehicles with integrated reminder technology, such as SensorSafe. Systems that default to “on” are most effective. Use education and technology together to prevent these tragedies. Real-life experiences, like that of Jennifer Stockburger, highlight the importance of these precautions. Combining awareness with practical strategies and technology can protect children from hot-car incidents.
Leave a Reply